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KMID : 1130620090050030146
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Journal of Clinical Neurology
2009 Volume.5 No. 3 p.146 ~ p.148
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Secondary Amyloidosis Associated with Multiple Sclerosis
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Kang Seok-Jae
Yi Joo-Hark
Hong Hyun-Seok
Jang Si-Hyung
Park Moon-Hyang
Kim Ho-Jung
Lee Kyu-Yong
Lee Yong-Joo
Han Sang-Woong
Koh Seong-Ho
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Abstract
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Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Secondary amyloidosis can occur as a complication of chronic systemic inflammatory and infectious diseases. Until now there has been no report of secondary amyloidosis associated with MS. We report herein a case of renal biopsy-proven secondary amyloidosis in a patient with MS.
Case Report: A 41-year-old woman with MS was hospitalized due to aggravated quadriparesis and edema in both lower extremities. Laboratory findings showed nephrotic-range proteinuria and hypoalbuminemia. A percutaneous renal biopsy procedure was performed, the results of which revealed secondary amyloid-A-type amyloidosis associated with MS.
Conclusions: This is the first report of secondary amyloidosis associated with MS.
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KEYWORD
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multiple sclerosis, secondary amyloidosis, nephrotic syndrome
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